Epigenetic control of innate and adaptive immune memory [ATAC-Seq]
Alternate Titles(s): Regulation of natural killer cells during MCMV infection
UID: 10380
Publisher(s): Memorial Sloan Kettering Cancer Center- Description
- Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrated that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and ‘memory’ NK cells possess distinct chromatin accessibility states, and that their epigenetic profiles reveal a ‘poised’ regulatory program at the memory stage. Furthermore, we elucidate how individual STAT proteins differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic imprinting during the generation of innate and adaptive lymphocyte memory.
Part of a SuperSeries accession comprised of:
Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]
Transcriptional regulation of adaptive NK and CD8 T cell responses [RNA-Seq]
Epigenetic control of innate and adaptive immune memory [ATAC-Seq]
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Access via GEO
ATAC-seq performed on NK cells harvested during in-vivo infection
Accession #: GSE108051Access via SRAATAC Sequence reads for 51 samples
Accession #: SRP126684Access via BioProjectAdditional information about overall initiative.
Accession #: PRJNA422290 - Access Restrictions
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Free to All
- Access Instructions
- The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
- Associated Publications
- Data Type
- Equipment Used
- Dataset Format(s)
- SRA, TAR, BED, BIGWIG
- Dataset Size
- 22.8 Gb (TAR of BIGWIG), 1,780 Kb (BED), 105.9 Gb (SRA)
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