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Discovery of a Drug Candidate for GLIS3-Associated Diabetes

UID: 10383

Author(s): Amin, Sadaf, Cook, Brandoch, Zhou, Ting*, Ghazizadeh, Zaniar, Lis, Raphael, Zhang, Tuo, Khalaj, Mona, Crespo, Miguel, Perera, Manuradhi, Xiang, Jenny Zhaoying, Zhu, Zengrong*, Tomishima, Mark J.*, Liu, Chengyang, Naji, Ali, Evans, Todd, Huangfu, Danwei*, Chen, Shuibing * MSK affiliated

Description
Comparison of WT and GLIS3-/- cells at various stages of human pancreatic differentiation.

From Gene Expression Omnibus authors' summary: "Through development and use of a minimal component protocol for derivation of late stage pancreatic progenitors and beta-like cells, we compared WT and GLIS3-/- pancreatic cells at different stages and discovered that GLIS3-/- cells show an ectopic activation of TGF-beta signaling."
Subject of Study
Homo sapiens
Subject(s)
Cell Differentiation/genetics
Diabetes Mellitus
Human Embryonic Stem Cells
Hypoglycemic Agents
Insulin-Secreting Cells
Transcription Factors
Access via GEO

Processed gene expression as SRA data
Accession #: GSE114051

Access via SRA

RNA Sequence reads for 14 samples
Accession #: SRP144623

Access via BioProject

Additional information about overall initiative.
Accession #: PRJNA463329

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus database provides open access to these files. SRA and/or tar files can be downloaded directly from the site or viewed in the NCBI SRA Run Selector (link at bottom of page).
Associated Publications
Amin S, Cook B, Zhou T, et al. Discovery of a drug candidate for GLIS3-associated diabetes. Nature Communications. 2018; 9:2681.
Data Type
Genomic
Equipment Used
Illumina HiSeq 4000

High throughput gene sequencing system

Dataset Format(s)
Plain Text, SRA
Dataset Size
1.3 MB (TXT), 10.1 GB (SRA)
Other Resources
Discovery of a Drug Candidate for GLIS3-Associated Diabetes (human) BioProject

The GSE114051 accession is part of the NCBI BioProject PRJNA463329

Data Catalog Record Updated
2021-11-04