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Acral Melanoma (TGEN, Genome Res 2017): Whole exome sequencing and transcriptome analysis of 34 Acral Melanoma patients (33 with matched normals)

UID: 10395

Author(s): Liang, Winnie S., Hendricks, William, Kiefer, Jeffrey, Schmidt, Jessica, Sekar, Shobana, Carpten, John, Craig, David W., Adkins, Jonathan, Cuyugan, Lori, Manojlovic, Zarko, Halperin, Rebecca F., Helland, Adrienne, Nasser, Sara, Legendre, Christophe, Hurley, Laurence H., Sivaprakasam, Karthigayini, Johnson, Douglas B., Crandall, Holly, Busam, Klaus J.*, Zismann, Victoria, Deluca, Valerie, Lee, Jeeyun, Sekulic, Aleksandar, Ariyan, Charlotte Eielson*, Sosman, Jeffrey, Trent, Jeffrey * MSK affiliated

Description
This dataset contains summary data visualizations and clinical data from a comprehensive genomic and transcriptomic analysis of 38 acral lentiginous melanomas (ALM) from 34 patients. The study was conducted to analyze ALM, a rare sun-shielded melanoma subtype of cutaneous melanoma (CM) which is associated with worse survival than other CM in an effort to delineate non-UV oncogenic mechanisms. The clinical data includes mutation count, information about mutated genes, patient demographics, disease status, therapeutic details and copy number alterations among other relevant data points.
Subject of Study
Homo sapiens
Subject(s)
Chromosome Aberrations
DNA Mutational Analysis
Melanoma/genetics
Melanoma/pathology
Transcriptome
OncoTree Cancer Type(s)
Acral Melanoma
Access via cBioPortal

Access Restrictions
Free to All
Access Instructions
This cBioPortal for Cancer Genomics dataset is publicly available for viewing online as tables, graphs, and/or charts. The data is also available for download in its entirety as a tarball or as individual TSV (tab separated value) files. Some features are only available by logging in with a Google or Microsoft account. These features include storing your virtual studies and groups which allows you to access your studies and groups from any computer, and to allow cBioPortal to remember your study view charts preferences for each study (i.e. order of the charts, type of charts and visibility). Login is optional and not required to access any of the other features of cBioPortal.
Associated Publications
Liang W, Hendricks W, Kiefer J, et al. Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. Genome Research. 2017; 27(4):524-532.
Data Type
Genomic
Dataset Format(s)
TSV, TAR
Dataset Size
8.6 MB
Data Catalog Record Updated
2021-10-19