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Anaplastic Oligodendroglioma and Anaplastic Oligoastrocytoma (MSKCC, Neuro Oncol 2017): Genomic characterization using next generation sequencing (NGS) in 22 Anaplastic Oligodendroglioma and Anaplastic Oligoastrocytomas.

UID: 10397

Author(s): Thomas, Alissa A.*, Abrey, Lauren E.*, Terziev, Robert*, Raizer, Jeffrey J.*, Martinez, Nina Leyson*, Forsyth, Peter, Paleologos, Nina, Matasar, Matthew J.*, Sauter, Craig Steven*, Moskowitz, Craig*, Nimer, Stephen D.*, De Angelis, Lisa*, Kaley, Thomas*, Grimm, Sean Aaron*, Louis, David N., Cairncross, J. Gregory, Panageas, Katherine S., Briggs, Samuel Royden*, Faivre, Geraldine M.*, Mohile, Nimish Arun*, Mehta, Jayesh, Jonsson, Karl Philip*, Chakravarty, Debyani*, Gao, Jianjiong*, Schultz, Nikolaus D.*, Brennan, Cameron*, Huse, Jason T.*, Omuro, Antonio Marcilio Padula* * MSK affiliated

Description
This dataset contains summary data visualizations and sequencing data of 22 anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) tumors from 19 patients following a trial using induction temozolomide (TMZ) followed by myeloablative high-dose chemotherapy (HDC) with autologous stem-cell transplant (ASCT) as a potential strategy to defer radiotherapy.

The clinical data includes mutation count, information about mutated genes, patient demographics, disease progression among other relevant data points. The data set also includes copy-number segment data downloadable as .seg files and viewable via the Integrative Genomics Viewer.
Subject of Study
Homo sapiens
Subject(s)
Brain Neoplasms
Chemoradiotherapy
DNA Mutational Analysis
Oligodendroglioma
Temozolomide
OncoTree Cancer Type(s)
Anaplastic Oligoastrocytoma
Anaplastic Oligodendroglioma
Access via cBioPortal

Access Restrictions
Free to All
Access Instructions
This cBioPortal for Cancer Genomics dataset is publicly available for viewing in tables or, for copy-number segments, via integrated IGV application. The data is also available for download in its entirety as a tarball or as individual TSV (tab separated value) or SEG files. Some features are only available by logging in with a Google or Microsoft account. These features include storing your virtual studies and groups which allows you to access your studies and groups from any computer, and to allow cBioPortal to remember your study view charts preferences for each study (i.e. order of the charts, type of charts and visibility). Login is optional and not required to access any of the other features of cBioPortal.

Downloaded SEG files (tab-delimited segmented data text files that list loci and associated numeric values) can be viewed by downloading and installing the Integrative Genomics Viewer desktop application.
Associated Publications
Thomas A, Abrey L, Terziev R, et al. Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma. Neuro-Oncology. 2017; 19(10):1380-1390.
Data Type
Genomic
Software Used
Integrative Genomics Viewer (IGV)

High-performance visualization tool for interactive exploration of large, integrated genomic datasets.

OncoTree

Open-source ontology that was developed at Memorial Sloan Kettering Cancer Center (MSK) for standardizing cancer type diagnosis from a clinical perspective by assigning each diagnosis a unique OncoTree code.

Dataset Format(s)
TSV, TAR, SEG
Dataset Size
49 KB
Other Resources
Clinicaltrials.gov registry

Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

Data Catalog Record Updated
2021-10-19