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Endometrial Cancer (MSK, 2018): MSK-IMPACT sequencing of 197 advanced-staged endometrial cancer tumor samples with matched normals, from 189 patients treated at MSK.

UID: 10447

Publisher(s): Memorial Sloan Kettering Cancer Center

Description
This dataset contains summary data visualizations and clinical data from a broad sampling of endometrial tumors. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Fraction Genome Altered, First-Line Therapy PFS, IHC Detail, MMR-D by IHC, MSI Status, Neoplasm Histologic Grade, POLE ultra-mutated, Progression Status, SCNA Cluster, and Oncotree Code. The data set also includes copy-number segment data downloadable as .seg files and viewable via the Integrative Genomics Viewer.
Subject of Study
Homo sapiens
Subject(s)
Carcinoma, Endometrioid
DNA Mutational Analysis
Endometrial Neoplasms
Uterine Neoplasms
OncoTree Cancer Type(s)
Uterine Clear Cell Carcinoma
Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor
Uterine Dedifferentiated Carcinoma
Uterine Endometrioid Carcinoma
Uterine Mixed Endometrial Carcinoma
Uterine Neuroendocrine Carcinoma
Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma
Uterine Undifferentiated Carcinoma
Access via cBioPortal

Access Restrictions
Free to All
Access Instructions
This cBioPortal for Cancer Genomics dataset is publicly available for viewing in tables or, for copy-number segments, via integrated IGV application. The data is also available for download in its entirety as a tarball or as individual TSV (tab separated value) or SEG files. Some features are only available by logging in with a Google or Microsoft account. These features include storing your virtual studies and groups which allows you to access your studies and groups from any computer, and to allow cBioPortal to remember your study view charts preferences for each study (i.e. order of the charts, type of charts and visibility). Login is optional and not required to access any of the other features of cBioPortal. Downloaded SEG files (tab-delimited segmented data text files that list loci and associated numeric values) can be viewed by downloading and installing the Integrative Genomics Viewer desktop application.
Associated Publications
Soumerai T, Donoghue M, Bandlamudi C, et al. Clinical utility of prospective molecular characterization in advanced endometrial cancer. Clinical Cancer Research. 2018; 24(23):5939-5947.
Data Type
Genomic
Software Used
Integrative Genomics Viewer (IGV)

High-performance visualization tool for interactive exploration of large, integrated genomic datasets.

OncoTree

Open-source ontology that was developed at Memorial Sloan Kettering Cancer Center (MSK) for standardizing cancer type diagnosis from a clinical perspective by assigning each diagnosis a unique OncoTree code.

Dataset Format(s)
TSV, TAR, SEG
Data Tool(s)
MSK-IMPACT
Dataset Size
424 KB
Data Catalog Record Updated
2021-11-04