Co-expression of genes with ERG in prostate cancers

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UID: 10537

Author(s): Boormans, Joost L., Trapman , Jan, Jenster, Guido

Description: Summary from the GEO: "ERG overexpression is the most frequent molecular alteration in prostate cancer. We analyzed different stages of prostate cancer to identify genes that were coexpressed with ERG overexpression. In primary prostate tumors, it was shown that TDRD1 expression was the strongest correlated gene with ERG overexpression and we suggest TDRD1 as a direct ERG target gene.
48 Prostate cancer samples from radical prostatectomies were included in this study. These samples contained more than 70% cancer and less than 30% stromal tissue. Each sample was analyzed once."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Prostate

Access via GEO
CEL sequencing data.
Accession #: GSE41408

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA177575
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Adams E, Karthaus W, Hoover E, et al. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. 2019; 571(7765):408-412.

Boormans JL, Korsten H, Ziel-van der Made AJ, van Leenders GJ, de Vos CV, Jenster G, Trapman J. Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer. Int J Cancer. 2013 Jul 15;133(2):335-45.
Data Type: Genomic
Equipment Used: Affymetrix Human Exon 1.0 ST Array
Software Used: GEO2R
Use GEO2R to compare two or more groups of Samples in order to identify genes that are differentially expressed across experimental conditions. Results are presented as a table of genes ordered by significance.
Dataset Format(s): TAR, CEL
Dataset Size: 1.0 Gb (TAR of CEL)

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