Quantitative Analysis of Endothelial Transcriptomes after Irradiation
UID: 10595
Publisher(s): Korea Institute of Radiological & Medical Sciences- Description
- Summary from the GEO: "Transcriptional profiling of HUVECs with or without irradiation."
Overall design from the GEO: " mRNA profiles of endothelial cells with or without irradiation were generated by deep sequencing using Illumina HiSeq X10. HUVEC cells were collected before and 5 and 72 hrs post-irradiation. Three biological replicates for each condition were sequenced."
The data was from a study on "Targeting the molecular pathways underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin (Dox) could reduce the morbidity and mortality associated with these anticancer treatments." The study found that, "Vascular endothelial cells (ECs) with persistent DNA damage induced by irradiation and Dox treatment exhibit a fibrotic phenotype (endothelial-mesenchymal transition, EndMT) correlating with the colocalization of L1CAM and persistent DNA damage foci."
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Access via GEO
Plain Text Data of expression profiling by high throughput sequencing
Accession #: GSE155285Access via SRARNA Sequence reads for 9 samples
Accession #: SRP273963Access via BioProjectAdditional information about overall initiative.
Accession #: PRJNA649244 - Access Restrictions
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Free to All
- Access Instructions
- The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
- Associated Publications
- Data Type
- Equipment Used
- Software Used
- Dataset Format(s)
- Plain Text, TAR
- Dataset Size
- 1.1 MB (TAR of TXT)
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