Molecular characterization of neuroendocrine prostate cancer organoids and PDOX by RNA-seq

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UID: 10598

Author(s): Puca, Loredana, Bareja, Rohan, Sboner, Andrea, Beltran, Himisha

Description: Summary from the GEO: "We report the generation and characterization of tumor organoids and PDOX derived from needle biopsies of metastatic lesions from neuroendocrine prostate cancer patients."

Overall design from the GEO: "Understanding the expression profile of neuroendocrine prostate cancer tumor organoids and PDOXs."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Prostate Neuroendocrine Carcinoma
Prostate

Access via GEO
Plain Text Data of expression profiling by high throughput sequencing
Accession #: GSE112786

Access via SRA
RNA Sequence reads for 9 samples
Accession #: SRP137893

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA449096
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Paris AJ, Hayer KE, Oved JH, et al. STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol. 2020;22(10):1197-1210.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2500
High throughput sequencing system
Software Used: SRA Toolkit
The NCBI SRA Toolkit enables reading ("dumping") of sequencing files from the SRA database and writing ("loading") files into the .sra format.
Dataset Format(s): Plain Text, SRA, TAR
Dataset Size: 1.3 MB (TAR of TXT), 44.2 GB (SRA)

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