Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
UID: 10602
Publisher(s): MD Anderson Cancer Center- Description
- Summary from BioProject: "Renal medullary carcinoma (RMC) is a highly lethal malignancy that mainly afflicts young individuals of African descent and is resistant to all targeted agents used to treat other renal cell carcinomas. Comprehensive genomic and transcriptomic profiling of untreated primary RMC tissues was performed to elucidate the molecular landscape of these tumors. We found that RMC was characterized by high replication stress and an abundance of focal copy number alterations associated with activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) innate immune pathway. Replication stress conferred a therapeutic vulnerability to drugs targeting DNA damage repair pathways. Elucidation of these previously unknown RMC hallmarks paves the way to new clinical trials for this rare but highly lethal malignancy."
Renal Medullary Carcinoma
Renal Cell Carcinoma
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Access via BioProject
Information about the experiment with access to sample data
Accession #: PRJNA605003Access via SRARNA Sequence reads for 17 samples
Accession #: PRJNA605003 - Access Restrictions
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Free to All
- Access Instructions
- NCBI BioProject and Sequence Read Archive databases provide open access to these files.
- Associated Publications
- Data Type
- Equipment Used
- Software Used
- Dataset Format(s)
- SRA
- Dataset Size
- 93.717 GB
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