Retinoblastoma (MSK, Cancers 2021): Targeted sequencing of 83 Retinoblastoma tumor-normal pairs via MSK-IMPACT. Genomic data provided is limited to somatic alterations.

UID: 10609

Publisher(s): Memorial Sloan Kettering Cancer Center

Description: This dataset contains the summary data visualizations and clinical data from targeted sequencing of 83 Retinoblastoma tumor-normal pairs from 81 patients via MSK-IMPACT. Genomic data provided is limited to somatic alterations.. Clinical data includes:Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Sex, Bilateral, Choroidal Invasion, Gain 1q, Hypertension diagnosis, LOH 16q, Matched Status, Optic Nerve Invasion, Prior Treatment, Rubeosis, Subretinal Seeds, Vitreous Seeds, Worse Prognosis. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file. The dataset includes copy-number segment data downloadable as .seg files and viewable via the Integrative Genomics Viewer.

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Eye
Retinoblastoma

Access via cBioPortal
Access Restrictions: Free to All
Access Instructions: This cBioPortal for Cancer Genomics dataset is publicly available for viewing in tables or, for copy-number segments, via integrated IGV application. The data is also available for download in its entirety as a tarball or as individual TSV (tab separated value) or SEG files. Some features are only available by logging in with a Google or Microsoft account. These features include storing your virtual studies and groups which allows you to access your studies and groups from any computer, and to allow cBioPortal to remember your study view charts preferences for each study (i.e. order of the charts, type of charts and visibility). Login is optional and not required to access any of the other features of cBioPortal.
Associated Publications: Francis J, Richards A, Mandelker D, et al. Molecular changes in retinoblastoma beyond RB1: Findings from next-generation sequencing. Cancers. 2021; 13(1):149.
Data Type: Genomic
Software Used: Integrative Genomics Viewer (IGV)
High-performance visualization tool for interactive exploration of large, integrated genomic datasets.
Dataset Format(s): TSV, TAR, SEG
Data Tool(s): MSK-IMPACT
Dataset Size: 94.4 KB (TAR), 8.6 KB (TSV), 212 KB (SEG)

Do you have or know of a dataset that should be added to the catalog? Let us know!