Whole exome sequencing of tumors from Brca1/Palb2/Brca2 and Trp53 model mice

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UID: 10634

Publisher(s): Memorial Sloan Kettering Cancer Center

Description: Description from BioProject: "In this study, we ablated, individually and in combination, Brca1, Brca2 and Palb2 along with one copy of Trp53 in the mouse mammary gland. We also studied spontaneous tumor development in Palb2 mutant mice with a mutation that disengages the BRCA1-PALB2 interaction, in Trp53 wt, heterozygous and homozygous null backgrounds. Whole exome sequencing was conducted for 35 mammary tumors and 36 other tumors in order to understand the genetic mechanisms of the cancer development."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Invasive Breast Carcinoma

Access via BioProject
Information about the experiment with access to sample data
Accession #: PRJNA544737

Access via SRA
Whole-Exome Sequencing of 81 Samples
Accession #: SRP199480
Access Restrictions: Free to All
Access Instructions: The NCBI BioProject and SRA databases provide open access to these files.
Associated Publications: Huo Y, Selenica P, Mahdi A, et al. Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development. npj Breast Cancer. 2021; 7:45.
Data Type: Genomic
Equipment Used: Illumina NextSeq 500
Software Used: SRA Toolkit
The NCBI SRA Toolkit enables reading ("dumping") of sequencing files from the SRA database and writing ("loading") files into the .sra format.
Dataset Format(s): SRA, BAM
Data Tool(s): WXS
Dataset Size: 482.25 GB (BAM), 485.5 Gb (SRA)

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