Metatranscriptomic Sequencing of Pre-Transplant Bronchoalveolar Lavage in Pediatric Stem Cell Transplant Patients

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UID: 10648

Author(s): Zinter, Matt, DeRisi, Joseph

Publisher(s): University of California San Francisco (UCSF)

Description: Study Description from dbGaP:
"Children with malignancies, immunodeficiencies, and other life-threatening diseases sometimes receive allogeneic hematopoietic cell transplantation (HCT) as a treatment for their disease. The HCT process can be complicated by the development of lung disease from infection, alloreactivity, or other causes. To identify patients at-risk for post-HCT lung disease, this study uses metatranscriptomic RNA sequencing of bronchoalveolar lavage (BAL) obtained prior to HCT. Sequencing results are associated with the development of post-HCT lung injury.

Study Design:
Prospective Longitudinal Cohort
Study Type:
Total number of consented subjects: 181"

181 phenotyped subjects

Subject of Study

Subject(s)

Access via dbGaP

Accession #: phs002208.v1.p1
Access Restrictions: Application Required
Access Instructions: Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link
Associated Publications: Zinter M, Lindemans C, Versluys B, et al. The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury. Blood. 2021; 137(12):1679-1689.
Data Type: Genomic
Dataset Format(s): PDF, TAR, gzip
Data Tool(s): RNA Seq
Dataset Size: 4 MB

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