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Multiple Myeloma Diagnosis to Relapse study samples (2017-04-27)

UID: 10659

Publisher(s): European Genome-phenome Archive

Description
Dataset Description from EGA: " The study will investigate serial samples from the same patient taken at the time of MGUS or SMM diagnosis, and later at the time of evolution towards MM. Samples will be sequenced by whole genome along with a matched normal to obtain the highest possible amount of information toinvestigate genomic changes at disease evolution. This dataset contains all the data available for this study on 2017-04-27. "

There are 139 Samples.
Subject of Study
Homo sapiens
Subject(s)
Monoclonal Gammopathy of Undetermined Significance
Smoldering Multiple Myeloma
OncoTree Cancer Type(s)
Plasma Cell Myeloma
Access via EGA

CRAM files of whole genome sequencing
Accession #: EGAD00001003309

Access Restrictions
Application Required
Access Instructions
The European Genome-Phenome Archive (EGA) provides a service for the permanent archiving and distribution of personally identifiable genetic and phenotypic data resulting from biomedical research projects. Data at EGA was collected from individuals whose consent agreements authorise data release only for specific research use to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project.

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Studies associated with the dataset are listed and linked by accession numbers at the bottom of the page.
Associated Publications
Oben B, Froyen G, Maclachlan K, et al. Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities. Nature Communications. 2021; 12:1861.
Rustad E, Nadeu F, Angelopoulos N, Ziccheddu B, Bolli N, Puente X, Campo E, Landgren O, Maura F. mmsig: A fitting approach to accurately identify somatic mutational signatures in hematological malignancies. Communications Biology. 2021; 4(1):424.
Data Type
Genomic
Equipment Used
Illumina HiSeq X Ten

Set of 10 ultra-high-throughput sequencers

Dataset Format(s)
CRAM
Data Tool(s)
WGS
Dataset Size
4.78 TB
Data Catalog Record Updated
2024-05-20