Initial WGS of plasma cell neoplasms in fire fighters exposed to the WTC attack
UID: 10661
- Description
- Dataset Description from EGA: " Initial WGS of plasma cell neoplasms in fire fighters exposed to the WTC attack "
There are 14 samples.
Abstract of the article associated with the dataset for a further explanation:
"Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are characterized by later initiation in the patient’s life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable. "
-
Access via EGA
BAM files of whole genome sequencing
Accession #: EGAD00001006896 - Access Restrictions
-
Application Required
- Access Instructions
- The European Genome-Phenome Archive (EGA) provides a service for the permanent archiving and distribution of personally identifiable genetic and phenotypic data resulting from biomedical research projects. Data at EGA was collected from individuals whose consent agreements authorise data release only for specific research use to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project.
To view dataset file format, size, location and QC Report click on the 'Browse files' button aligned to the right of the dataset title. A Comma Separated Value (CSV) file of this information can be downloaded.
Each dataset is covered by a Data Access Agreement (DAA), which defines the terms and conditions of use for the specified dataset. Specific requirements for access to the dataset are represented by buttons representing terms covered by the 'Data Use Conditions' in the link below.
To access files an EGA account is created by the DAC for an individual user, in response to a successful application to access single or multiple datasets. Datasets are downloaded using the EGA Download Client, which provides instant access to all approved files, which may be filtered and downloaded by dataset.
Studies associated with the dataset are listed and linked by accession numbers at the bottom of the page. - Associated Publications
- Data Type
- Equipment Used
-
Illumina NovaSeq 6000
- Dataset Format(s)
- BAM
- Data Tool(s)
-
WGS
- Dataset Size
- 957 GB
Do you have or know of a dataset that should be added to the catalog? Let us know!