Search Tips

Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile

UID: 10662

Author(s): Sagar, Lonial, Fiona, An

Publisher(s): Multiple Myeloma Research Foundation

Description
Study Description from dbGaP: "The Multiple Myeloma Research Foundation (MMRF) CoMMpass (Relating Clinical Outcomes in MM to Personal Assessment of Genetic Profile) trial (NCT01454297) is a longitudinal observation study of 1000 newly diagnosed myeloma patients receiving various standard approved treatments that aim at collecting tissue samples, genetic information, Quality of Life (QoL) and various disease and clinical outcomes over 10 years."

The dataset includes WGS, WXS, and RNA-Seq sequencing data of 5026 samples.
Subject of Study
Homo sapiens
Subject(s)
Multiple Myeloma
Neoplasms, Plasma Cell
OncoTree Cancer Type(s)
Plasma Cell Myeloma
Access via dbGaP

BAM and SRA files of whole genome, exome and RNA sequencing
Accession #: phs000748.v7.p4

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded.

A full list of and information about the SRA runs, BioSamples, and experiments is publicly viewable by going to the 'Molecular Datasets' tab and clicking on 'RunSelector' at the bottom of the page. This will take you to the NCBI SRA Run Selector platform. View and download of the datasets themselves, however, still requires authorization through dbGaP.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Oben B, Froyen G, Maclachlan K, et al. Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities. Nature Communications. 2021; 12:1861.
Keats JJ, Craig DW, Liang W, et al. Interim Analysis Of The MMRF CoMMpass Trial, a Longitudinal Study In Multiple Myeloma Relating Clinical Outcomes To Genomic and Immunophenotypic Profiles. Blood 2013; 122:532.
Data Type
Genomic
Equipment Used
Illumina HiSeq 2500

High throughput sequencing system

Software Used
SRA Toolkit

The NCBI SRA Toolkit enables reading ("dumping") of sequencing files from the SRA database and writing ("loading") files into the .sra format.

Dataset Format(s)
SRA, BAM
Data Tool(s)
RNA Seq
WXS
WGS
Dataset Size
44.41 TB
Data Catalog Record Updated
2021-07-06