PD-1-targeted immunotherapy in non-alcoholic steatohepatitis-induced liver cancer induces a pro-tumorigenic environment through CD8+ PD1+ T-cells.

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UID: 10668

Description: Summary from the ENA: "Mice with advanced non alcoholic fatty liver disease (NASH) by dietary feeding regime of choline deficient high fat diet (CD-HFD) were treated with antibodies (a-CD8 depletion; a-PD1 checkpoint inhibition; Co-depletion by a-CD8 and a-NK1.1 administration) for 8 weeks. Surprisingly, a-CD8 depletion prevented hepatocarcinogenesis; in contrast a-PD1 checkpoint inhibition induced hepatocarcinogenesis. By RNA-Seq of liver tissue, we want to investigate changes on RNA level induced by the different treatment regimes in the background of advanced NASH and hepatocarcinogenesis."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Hepatocellular Carcinoma

Access via ENA
RNA sequencing in 70 FASTQ files
Accession #: PRJEB36747
Access Restrictions: Free to All
Access Instructions: Data is publicly available via the European Nucleotide Archive for download in FASTQ format in gzip file. JSON and TSV reports containing fields selected by the user can be downloaded to view the contents of the dataset.
Associated Publications: Pfister D, Núñez N, Pinyol R, et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature. 2021; 592(7854):450-456.
Data Type: Genomic
Equipment Used: Illumina NextSeq 500
Dataset Format(s): FASTQ
Data Tool(s): RNA Seq
Dataset Size: 10 GB

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PD-1-targeted immunotherapy in non-alcoholic steatohepatitis-induced liver cancer induces a pro-tumorigenic environment through CD8+ PD1+ T-cells.​​