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Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

UID: 10684

Description
Dataset Description from EGA: "Sequencing of untreated pancreatic cancer metastases and primary tumor sections. "

Abstract from the MSK Synapse article to further understand the dataset in EGA:

"The extent of heterogeneity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive metastatic disease-is largely unknown. To address this issue, we carried out 60x whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in every metastatic lesion for each patient studied. Passenger gene mutations, which do not have known or predicted functional consequences, accounted for all intratumoral heterogeneity. Even with respect to these passenger mutations, our analysis suggests that the genetic similarity among the founding cells of metastases was higher than that expected for any two cells randomly taken from a normal tissue. The uniformity of known driver gene mutations among metastases in the same patient has critical and encouraging implications for the success of future targeted therapies in advanced-stage disease."
Subject of Study
Subject(s)
OncoTree Cancer Type(s)
Pancreas
Access via EGA

49 BAM files of whole genome sequencing
Accession #: EGAD00001003153

Access Restrictions
Application Required
Access Instructions
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Associated Publications
Data Type
Equipment Used
Illumina HiSeq 2000
Illumina HiSeq 2500
Dataset Format(s)
BAM
Dataset Size
GB
Data Catalog Record Updated
2021-10-26