Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer
UID: 10684
- Description
- Dataset Description from EGA: "Sequencing of untreated pancreatic cancer metastases and primary tumor sections. "
Abstract from the MSK Synapse article to further understand the dataset in EGA:
"The extent of heterogeneity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive metastatic disease-is largely unknown. To address this issue, we carried out 60x whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in every metastatic lesion for each patient studied. Passenger gene mutations, which do not have known or predicted functional consequences, accounted for all intratumoral heterogeneity. Even with respect to these passenger mutations, our analysis suggests that the genetic similarity among the founding cells of metastases was higher than that expected for any two cells randomly taken from a normal tissue. The uniformity of known driver gene mutations among metastases in the same patient has critical and encouraging implications for the success of future targeted therapies in advanced-stage disease."
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Access via EGA
49 BAM files of whole genome sequencing
Accession #: EGAD00001003153 - Access Restrictions
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Application Required
- Access Instructions
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Studies associated with the dataset are listed and linked by accession numbers at the bottom of the page. - Associated Publications
- Data Type
- Equipment Used
- Dataset Format(s)
- BAM
- Dataset Size
- GB
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