Loss of CREBBP results in H3K27ac loss at enhancers in lymphoma cells

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UID: 10688

Author(s): Jiang, Yanwen, Geng, Huimin, Melnick, Ari M.

Description: Summary from the GEO: "KD of CREBBP at lymphoma cell line, MD901, results in reduced H3K27ac enrichment at a subset of promoters and enhancers. Genome-wide H3K27Ac ChIPseq binding sites in human cell line MD901 (CREBBP wild type) with shCREBBP (11027 and 3752) and scramble control."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Lymphoid

Access via GEO
Raw, BIGBED, and BigWig sequencing data.
Accession #: GSE79639

Access via SRP072422
ChIP-Seq reads for 17 samples.
Accession #: SRP072422

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA316577
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Jiang Y, Ortega-Molina A, Geng H, et al. CREBBP inactivation promotes the development of HDAC3-dependent lymphomas. Cancer Discovery. 2017; 7(1):38-53.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2000
High throughput gene sequencing system
Dataset Format(s): SRA, TAR, BIGWIG, RAW, BIGBED
Dataset Size: 2.7 Gb (TAR [of BIGBED, BW] ), 20 Gb (SRA)

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