Loss of CREBBP results in H3K27ac loss at enhancers in mouse lymphoma cells

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UID: 10690

Author(s): Jiang, Yanwen, Geng, Huimin, Melnick, Ari M.

Description: Summary from the GEO: "KD of Crebbp at mouse cells results in reduced H3K27ac enrichment at a subset of promoters and enhancers. Genome-wide H3K27Ac ChIPseq binding sites in mouse cells with shCrebbp and scramble control."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Lymphoid

Access via GEO
Raw, BIGBED, and BigWig sequencing data.
Accession #: GSE79640

Access via SRA
ChIP-Sequence reads for 20 samples
Accession #: SRP072421

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA316576
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Jiang Y, Ortega-Molina A, Geng H, et al. CREBBP inactivation promotes the development of HDAC3-dependent lymphomas. Cancer Discovery. 2017; 7(1):38-53.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2000
High throughput gene sequencing system
Dataset Format(s): SRA, TAR, BIGWIG, BIGBED
Dataset Size: 3.6 Gb (TAR of BigWig and BIGBED), (SRA)

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