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Examining alterations in gene expression of LNCaP-Ctrl (PSMA +ve) vs LNCaP-KD (PSMA -ve) cells

UID: 10691

Author(s): Kaittanis, Charalambos*, Hieronymus, Haley * MSK affiliated

Publisher(s): GCMI, Massachusetts General Hospital

Description
Summary from the GEO: "The biological role of PSMA, a biomarker expressed in prostate cancer and by the neovasculature of solid tumors, remains unknown. Although PSMA processes folates in our duodenum, and in the brain cleaves NAAG to control neuronal signaling, little is known about its role in cancer.
We used microarrays to detail the glonal perturbations in gene expression in the absence of PSMA, in order to identify disease-specific driving pathways that may lead to new therapies for cancer."

Overall design from the GEO: "LNCaP-Ctrl (PSMA +ve) cells grown on Petri dishes and in complete media where compared with LNCaP cells lacking PSMA (Platinum Select retroviral shRNA-mir platform DU53991)"
Subject of Study
Subject(s)
OncoTree Cancer Type(s)
Prostate
Access via GEO

CEL files of expression profiling by array
Accession #: GSE104417

Access via BioProject

Additional information about the overall initiative.
Accession #: PRJNA412567

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications
Data Type
Equipment Used
Software Used
GEO2R
Dataset Format(s)
TAR, CEL
Dataset Size
11.2 MB (TAR of CEL)
Data Catalog Record Updated
2021-10-14