Peptidomimetic blockade of MYB in acute myeloid leukemia

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UID: 10694

Publisher(s): Memorial Sloan Kettering Cancer Center

Description: Summary from the GEO: "This SuperSeries is composed of the SubSeries: GSE94240, GSE94241, GSE107078"

A potential pharmacological therapeutic strategy for Acute Myeloid Leukemia (AML) was analyzed with the deposited experiments. Using structure-guided molecular design, a prototypical peptidomimetic inhibitor, MYBMIM, was developed and shown to interfere with the molecular assembly of AML cells. MYBMIM may be an effective therapeutic blockade against MYB-driven gene trans-activation with CREB-binding proteins.

The superseries provides access and download of unprocessed data coordinated by sequencing category in the subseries.

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Acute Myeloid Leukemia

Access via GEO
BIGWIG file of expression and genome binding/occupancy profiling by high throughput sequencing
Accession #: GSE94242

Access via BioProject
Additional information about the overall initiative.
Accession #: PRJNA369117
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Ramaswamy K, Forbes L, Minuesa G, et al. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature Communications. 2018; 9:110.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2500
High throughput sequencing system
Dataset Format(s): TAR, BIGWIG
Dataset Size: 3.7 GB (TAR of BIGWIG)

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