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Glioma International Case Control Study (GICC)

UID: 10713

Author(s): Bondy, Melissa L.

Description
Study Description from dbGaP: "The main goals of the GICC Study were: 1) to identify novel genetic risk variants for glioma, as well as validate variants implicated by previous genome-wide association studies of glioma; and 2) to explore biologically relevant gene-gene and gene-environment interactions in glioma susceptibility."

Study Inclusion Criteria: "Diagnosis of histologically confirmed, supratentorial, intracranial glioma (World Health Organization (WHO) grades II-IV): fibrillary astrocytoma (International Classification of Diseases, Ninth Revision, code 9420/3), protoplasmic astrocytoma (code 9410/3), gemistocytic astrocytoma (code 9411/3), oligodendroglioma (code 9450/3), oligoastrocytoma (code 9382/3), anaplastic astrocytoma (code 9401/3), anaplastic oligodendroglioma (code 9451/3), anaplastic oligoastrocytoma (code 9382/3), or glioblastoma (code 9440/3)
Age 18-80 years at diagnosis
Ability to speak the local language"
Subject of Study
Homo sapiens
Subject(s)
Astrocytoma
Brain Neoplasms
Glioblastoma
Glioma
Oligodendroglioma
OncoTree Cancer Type(s)
Anaplastic Astrocytoma
Anaplastic Oligoastrocytoma
Anaplastic Oligodendroglioma
Astrocytoma
Diffuse Glioma
Glioblastoma
Oligoastrocytoma
Oligodendroglioma
Access via dbGaP

Summaries and access instructions of seven consent groups for WGS sequencing data of 7566 study participants
Accession #: phs001319.v1.p1

Access Restrictions
Application Required
Access Instructions
Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded.

Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link.
Associated Publications
Melin B, Barnholtz-Sloan J, Wrensch M, et al. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nature Genetics. 2017; 49(5):789-794.
Amirian E, Armstrong G, Zhou R, et al. The Glioma International Case-Control Study: A report from the Genetic Epidemiology of Glioma International Consortium. American Journal of Epidemiology. 2016; 183(2):85-91.
Takahashi H, Cornish A, Sud A, et al. Mendelian randomisation study of the relationship between Vitamin D and risk of glioma. Scientific Reports. 2018; 8:2339.
Data Type
Genomic
Equipment Used
Illumina Consortium-OncoArray_15047405
Dataset Format(s)
Plain Text, PLINK
Data Tool(s)
Whole Genome Genotyping
Dataset Size
1.5 GB
Data Catalog Record Updated
2021-07-15