Cohort-Based Genome-Wide Association Study of Glioma (GliomaScan)
UID: 10714
- Description
- Study Description from dbGaP: "We conducted a new independent GWAS of adult glioma using 1,856 cases and 4,955 controls from 14 cohort studies belonging to the Cohort Consortium, 3 case-control studies, and 1 population-based case only study. Cases were newly diagnosed glioma [ICDO-3 codes 9380-9480 or equivalent], and controls were cancer-free at the time of glioma diagnosis. We found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to higher grade tumors being captured in the cohort studies. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk."
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Access via dbGaP
Analysis and description of a WGS study including 1,856 cases and 4,955 controls from 14 cohort studies
Accession #: phs000652.v1.p1Access via BioProjectAccess to BioSample Links
Accession #: PRJNA215132Access via BioProjectAccess to BioSample Links
Accession #: PRJNA215133 - Access Restrictions
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Application Required
- Access Instructions
- Full access to this dataset in dbGaP requires authorization through an Authorized Access Portal which can be requested for either 'data download' or 'view only'. Individual level data download requires a project request. With dbGaP DataBrowser approval, users may view the compilation of individual-level data of general research use. Upon approval, data can be downloaded.
The Analysis tab grants displays plots generated by dbGaP based on the data submitted. This tab also links to the dbGaP Genome browser, an online platform with sequence viewer to access SNP bins mapped to genome coordinates.
Publicly available data such as data dictionaries, variable summaries, documents and truncated analysis are available the public download site FTP link. - Associated Publications
- Data Type
- Equipment Used
- Dataset Format(s)
- Plain Text
- Data Tool(s)
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Whole Genome Genotyping
- Dataset Size
- 74 GB
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