Ultraviolet radiation drives mutations in a subset of mucosal melanomas
UID: 10787
- Description
- Study Description from EGA: " Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We present the largest cohort of mucosal melanomas of conjunctival origin to be analyzed by whole genome sequencing and show a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset could benefit from treatments currently used for common cutaneous melanoma. "
Dataset Description from EGA: "This dataset contains 20 whole genome sequences from 10 tumor-normal pairs from conjunctival melanomas. "
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Access via EGA
BAM files of 20 Samples
Accession #: EGAD00001006568 - Access Restrictions
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Application Required
- Access Instructions
- The European Genome-Phenome Archive (EGA) provides a service for the permanent archiving and distribution of personally identifiable genetic and phenotypic data resulting from biomedical research projects. Data at EGA was collected from individuals whose consent agreements authorise data release only for specific research use to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project.
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Studies associated with the dataset are listed and linked by accession numbers at the bottom of the page. - Associated Publications
- Data Type
- Dataset Format(s)
- BAM
- Data Tool(s)
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WGS
- Dataset Size
- 4.2 TB
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