MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression
UID: 10796
- Description
- Summary from the GEO: "Misregulation of long non-coding RNA genes has been linked to a wide variety of cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo. MaTAR25 functions by interacting with purine rich element binding protein B, and associating with a major downstream target gene Tensin 1 (Tns1) to regulate its expression in trans. Knockout of MaTAR25 results in down-regulation of Tns1 leading to a reorganization of the actin cytoskeleton, and a reduction of focal adhesions and microvilli. The human ortholog of MaTAR25, LINC01271, is upregulated with human breast cancer stage and metastasis.""
Overall design from the GEO: " RNA-seq: Transcriptome profiles of MaTAR25 control and KO cells
ChIRP-seq: Chromatin Immunoprecipitation by RNA Purification (ChIRP) - seq of MaTAR25 in mammary tumor cells to identify MaTAR25 target genes"
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Access via GEO
Plain text files of expression profiling by high throughput sequencing
Accession #: GSE142169Access via SRARNA and ChIRP seq files from 26 samples
Accession #: SRP237913Access via BioProjectAdditional information about the overall inititative.
Accession #: PRJNA596185 - Access Restrictions
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Free to All
- Access Instructions
- The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files. The SRA Run Selector link at the bottom of the page is a processing tool for raw data.
- Associated Publications
- Data Type
- Equipment Used
- Software Used
- Dataset Format(s)
- Plain Text, SRA, TAR
- Data Tool(s)
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RNA SeqChIRP Seq
- Dataset Size
- 11.1 MB (TXT), 2.0 Mb (TAR of TXT), 22.5 GB (SRA)
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