Divergent role for STAT5 in the adaptive responses of natural killer cells
UID: 10805
- Description
- Summary from the GEO: "Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the role of this transcription factor and its upstream cytokines IL-2 and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. We demonstrate that STAT5 is induced in NK cells by IL-12 and STAT4 early after infection, and that partial STAT5 deficiency results in a defective capacity of NK cells to generate long-lived memory cells. Furthermore, we find a functional dichotomy of IL-2 and IL-15 signaling outputs during viral infection, whereby both cytokines drive clonal expansion, but only IL-15 is required for memory NK cell survival. We thus highlight a novel role for STAT5 signaling in promoting an optimal antiviral NK cell response."
Overall design from the GEO: "RNA-seq was performed on Ly49H+ NK cells harvested during in vivo MCMV infection."
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Access via GEO
Plain text files of expression profiling by high throughput sequencing
Accession #: GSE142821Access via SRARNA sequencing of 12 samples.
Accession #: SRP239264Access via BioProjectAdditional information about the overall inititative.
Accession #: PRJNA598546 - Access Restrictions
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Free to All
- Access Instructions
- The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files. The SRA Run Selector link at the bottom of the page is a processing tool for raw data.
- Associated Publications
- Data Type
- Equipment Used
- Software Used
- Dataset Format(s)
- Plain Text
- Data Tool(s)
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RNA Seq
- Dataset Size
- 830 KB (Plain text), 16.7 Gb (SRA)
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