Deconvoluting global cytokine signaling networks in natural killer cells

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UID: 10809

Author(s): Lau, Colleen M.* * MSK affiliated

Description: This super series contains has three subseries with containing datasets of RNA, ATAC and ChIP sequencing. The overall experiment was designed to deconstruct and and rebuild the interaction of major STAT (signal transducer and activator of transcription) signaling pathways in NK cells. The experiment develops some understanding of cytokine signaling pathways as a resource for improving cellular immunotherapy.

Subject of Study

Subject(s)

Access via GEO
TAR of RAW and BIGWIG data files
Accession #: GSE140044

Access via BioProject
Additional information about the overall initiative.
Accession #: PRJNA588077
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Wiedemann G, Santosa E, Grassmann S, et al. Deconvoluting global cytokine signaling networks in natural killer cells. Nature Immunology. 2021; 22(5):627-638.
Data Type: Genomic
Equipment Used: Illumina HiSeq 2500
High throughput sequencing system

Illumina HiSeq 4000
High throughput gene sequencing system
Dataset Format(s): TAR, BIGWIG, RAW
Data Tool(s): RNA Seq

ChIP Seq

ATAC Seq
Dataset Size: 20.5 Gb

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