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Characterizing an HSF1-dependent transcriptional program in metastatic lung adenocarcinoma

UID: 10813

Summary from the GEO: "The purpose of this study was to identify gene targets differentially regulated by shRNA-mediated knockdown of the HSF1 transcription factor in the brain-metastatic lung adenocarcinoma cell line PC9-BrM3."

Overall design from the GEO: "Samples were analyzed for differential gene expression in PC9-BrM3 cells transduced with shRNAs against NTC (non-target control) versus HSF1. Additionally, differential expression analysis was performed on another set of samples comparing PC9 parental versus PC9-BrM3 cells to identify genes differentially expressed relevant to brain metastasis."
Subject of Study
OncoTree Cancer Type(s)
Lung Adenocarcinoma
Access via GEO

Plain text files of expression profiling by high throughput sequencing
Accession #: GSE149246

Access via SRA

RNA sequencing of 8 samples.
Accession #: SRP258163

Access via BioProject

Additional information about the overall inititative.
Accession #: PRJNA627725

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files. The SRA Run Selector link at the bottom of the page is a processing tool for raw data.
Associated Publications
Data Type
Equipment Used
Illumina HiSeq 2000
Software Used
SRA Toolkit
Dataset Format(s)
Plain Text
Data Tool(s)
Dataset Size
37.5 MB
Data Catalog Record Updated