A Study to Evaluate Denosumab in Young Patients With Primary Breast Cancer (D-Beyond)
UID: 10817
- Description
- Description from the EGA: " This is a prospective, single arm phase IIa trial in which patients with early breast cancer will receive pre-operatively two doses of denosumab 120mg subcutaneously one week apart (maximum 12 days) followed by surgery. Tumor, normal breast tissue and blood samples will be collected at baseline and at surgery. Post-operative treatment will be at the discretion of the investigator.Primary objective: to determine if a short course of RANKL inhibition with denosumab can induce a decrease in tumor proliferation rates as determined by Ki67 immunohistochemistry (IHC) in newly diagnosed, early stage breast cancer in pre-menopausal women. "
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Access via EGA
RNA Sequencing of 144 samples.
Accession #: EGAD00001004391 - Access Restrictions
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Application Required
- Access Instructions
- The European Genome-Phenome Archive (EGA) provides a service for the permanent archiving and distribution of personally identifiable genetic and phenotypic data resulting from biomedical research projects. Data at EGA was collected from individuals whose consent agreements authorise data release only for specific research use to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project.
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Studies associated with the dataset are listed and linked by accession numbers at the bottom of the page. - Associated Publications
- Data Type
- Equipment Used
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Illumina NovaSeq 6000
- Dataset Format(s)
- FASTQ
- Data Tool(s)
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RNA Seq
- Dataset Size
- 356.57 GB
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