Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

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UID: 10825

Author(s): Bullinger, Lars

Description: Summary from the GEO: "RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL1 oncoprotein to induce an aggressive leukemia. MSI2 is overexpressed in human myeloid leukemia cell lines, and its depletion leads to decreased proliferation and increased apoptosis. Expression levels in human myeloid leukemia directly correlate with decreased survival in patients with the disease, thereby defining MSI2 expression as a new prognostic marker and as a new target for therapy in acute myeloid leukemia (AML).
Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc."

Subject of Study

Subject(s)

Access via GEO
TAR Sequencing Data.
Accession #: GSE16432

Access via BioProject
Additional information about overall initiative.
Accession #: PRJNA129033
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files.
Associated Publications: Nguyen D, Lu Y, Chu K, et al. HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nature Communications. 2020; 11:2026.
Data Type: Genomic
Equipment Used: SMD Print_621

SMD Print_677

SMD Print_771
Dataset Format(s): TAR, RAW
Dataset Size: 13.1 Mb

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