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RNA-seq for UBR5-regulated genes in tumor associated macrophages

UID: 10827

Author(s): Song, Mei, Zhang, Tuo

Description
Summary from the GEO: "RNA-seq analysis of peritoneal macrophages derived from non-tumor bearing, WT ID8 tumor-bearing, and Ubr5 KO ID8 tumor bearing C57BL/6 mice."

From the publication abstract: "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular pathways involved in the OC-TME interactions, how the crosstalk impinges on OC aggression and chemoresistance are not well-characterized...
This work provides mechanistic insights into the novel oncogene-like functions of UBR5in regulating the OC-TME crosstalk and suggests that UBR5 is a potential therapeutic target in OC treatment for modulating the TME and cancer stemness."
Subject of Study
Subject(s)
OncoTree Cancer Type(s)
Ovary/Fallopian Tube
Access via GEO

XLS file of expression profiling by high throughput sequencing
Accession #: GSE158911

Access via SRA

RNA sequencing of 3 samples.
Accession #: SRP286132

Access via BioProject

Additional information about the overall inititative.
Accession #: PRJNA666933

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files. The SRA Run Selector link at the bottom of the page is a processing tool for raw data.
Associated Publications
Data Type
Equipment Used
Illumina NovaSeq 6000
Software Used
SRA Toolkit
Dataset Format(s)
Microsoft Excel
Data Tool(s)
RNA Seq
Dataset Size
1.2 MB
Data Catalog Record Updated
2023-12-07