RNA-seq for UBR5-regulated genes in tumor associated macrophages
UID: 10827
- Description
- Summary from the GEO: "RNA-seq analysis of peritoneal macrophages derived from non-tumor bearing, WT ID8 tumor-bearing, and Ubr5 KO ID8 tumor bearing C57BL/6 mice."
From the publication abstract: "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular pathways involved in the OC-TME interactions, how the crosstalk impinges on OC aggression and chemoresistance are not well-characterized...
This work provides mechanistic insights into the novel oncogene-like functions of UBR5in regulating the OC-TME crosstalk and suggests that UBR5 is a potential therapeutic target in OC treatment for modulating the TME and cancer stemness."
-
Access via GEO
XLS file of expression profiling by high throughput sequencing
Accession #: GSE158911Access via SRARNA sequencing of 3 samples.
Accession #: SRP286132Access via BioProjectAdditional information about the overall inititative.
Accession #: PRJNA666933 - Access Restrictions
-
Free to All
- Access Instructions
- The NCBI Gene Expression Omnibus, SRA, and BioProject databases provide open access to these files. The SRA Run Selector link at the bottom of the page is a processing tool for raw data.
- Associated Publications
- Data Type
- Equipment Used
-
Illumina NovaSeq 6000
- Software Used
- Dataset Format(s)
- Microsoft Excel
- Data Tool(s)
-
RNA Seq
- Dataset Size
- 1.2 MB
Do you have or know of a dataset that should be added to the catalog? Let us know!