Mechanisms of muscle degeneration in Drosophila third instar larval musculature upon Tropomodulin (Tmod) knockdown

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UID: 10911

Author(s): Zapater i Morales, Carolina*, Baylies, Mary K.* * MSK affiliated

Description: Summary from GEO:

"The knockdown of Tmod, an actin-capping protein, decreases the expression of proteasomal degradation genes and increase expression of oxidative metabolism genes. It is also critical for the correct expression of larval actin isoforms."

Overall design from GEO:

"Performed gene expression profiling analysis using data obtained from RNA-seq of 2 experimental groups (tmodRNAi vs mCherryRNAi), with 3 samples each. Each sample contains the transcriptome of 7-10 Drosophila larva muscle enriched lysates."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE210507

Access via BioProject

Accession #: PRJNA865925
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provides open access to these files.
Associated Publications: Morales C, Carman P, Soffar D, Windner S, Dominguez R, Baylies M. Drosophila Tropomodulin is required for multiple actin-dependent processes within developing myofibers. Development. 2023; 150(6):dev201194.
Equipment Used: Illumina HiSeq 4000
High throughput gene sequencing system
Dataset Format(s): CSV
Dataset Size: 677.8 KB

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