SLAM-seq on INTS11-degron cells

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UID: 10922

Author(s): Wang, Hua* * MSK affiliated

Description: Summary from GEO

"Here, we showed that acute lost H3K4me3 induces rapid reduction in global transcription with progressively increase in magnitude over the time-course cooccurrence with lost all H3K4 methylations."

Overall design from GEO:

"To define the primary effects of rapid INTS11 removal on transcription, we measured the synthesis of newly transcribed RNAs using a Thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM-seq) with a time-course in the INTS11-FKBP dTAG degron cells."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE230124

Access via BioProject

Accession #: PRJNA957696
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Wang H, Fan Z, Shliaha P, Miele M, Hendrickson R, Jiang X, Helin K. H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature. 2023; 615(7951):339-348.
Equipment Used: Illumina NextSeq 550
Sequencing and array capabilities for transcriptome, targeted resequencing and genotype sequencing
Dataset Format(s): TSV, TAR
Dataset Size: 25.2 MB

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