TCR affinity defines tumor-specific CD8 T cell differentiation and dysfunction [ATAC-seq]

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UID: 10929

Author(s): Schietinger, Andrea*, Shakiba, Mojdeh*, Zumbo, Paul, Dunbar, Andrew*, Betel, Doron* * MSK affiliated

Description: Summary from GEO:

"ATACseq analysis of tumor-infiltrating CD8 T cells encountering high (F6) or low (D4) affinity tumor antigen."

Overall design from GEO:

"Transgenic antigen-specific CD8 T cells were adoptively transferred into tumor-bearing mice, isolated and flow-sorted from tumors 14 days post-transfer for subsequent ATAC-seq analysis. MCA 205 tumor cell lines were generated to express a defined tumor-specific model antigen, SV40 large T antigen epitope-I (TAG), as altered peptide ligands (APL), recognized by antigen-specific TCR SV40-I CD8 T cells with varying affinities (high/intermediate affinity F6, and low affinity D4). Naive antigen-specific TCR SV40-I CD8 T cells were used as controls."

Subject of Study

Subject(s)

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