Quiescent human glioblastoma cancer stem cells mediate tumor initiation, expansion, and recurrence following chemotherapy

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UID: 10934

Author(s): Xie, Xuanhua P.*, Laks, Dan R.*, Ganbold, Mungunsarnai*, Parada, Luis F.* * MSK affiliated

Description: Summary from GEO:

"We performed single cell RNA sequencing with eight patient derived xenograft samples to identify quiescent cancer stem cells in glioblastoma. Additionally two samples treated with temozolomide was sequenced to examine the evolution of the cancer stem cells upon chemotherapeutics."

Overall design from GEO:

"Whole transcriptome single cell RNA sequencing with 10X method."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Glioblastoma

Access via GEO

Accession #: GSE190129

Access via BioProject

Accession #: PRJNA785966

Access via SRA

Accession #: SRP349152
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, BioProject, and SRA databases provide open access to these files.
Associated Publications: Xie X, Laks D, Sun D, Ganbold M, Wang Z, Pedraza A, Bale T, Tabar V, Brennan C, Zhou X, Parada L. Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. Developmental Cell. 2022; 57(1):32-46.e8.
Equipment Used: Illumina HiSeq 4000
High throughput gene sequencing system

Illumina NovaSeq 6000
Dataset Format(s): CSV, TAR, TXT
Dataset Size: 152.9 MB (TAR), 501.4 KB (CSV), 641.2 KB (CSV)

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