RNA-seq identifies differential expressed genes upon YTHDC1 knockdown in MOLM13 human acute myeloid leukemia cells

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UID: 10956

Author(s): Cheng, Yuanming*, Chu, Karen*, Kharas, Michael G.* * MSK affiliated

Description: Summary from GEO:

"The goal of this study is to identify differential expressed genes upon YTHDC1 depletion in MOLM13 cells(AML)."

Overall design from GEO:

"RNAs were purified from MOLM13 cells transduced with control and YTHDC1 shRNAs and then used for RNA-seq."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Acute Myeloid Leukemia

Access via GEO

Accession #: GSE168565

Access via BioProject

Accession #: PRJNA708303

Access via SRA

Accession #: SRP309987
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus, BioProject, and SRA databases provide open access to these files.
Associated Publications: Cheng Y, Xie W, Pickering B, Chu K, Savino A, Yang X, Luo H, Nguyen D, Mo S, Barin E, Velleca A, Rohwetter T, Patel D, Jaffrey S, Kharas M. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021; 39(7):958-972.e8.
Equipment Used: Illumina HiSeq 4000
High throughput gene sequencing system
Dataset Format(s): Microsoft Excel
Dataset Size: 3.3 MB

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