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Control of nutrient uptake by IRF4 orchestrates innate immune memory - scRNA-seq

UID: 11007

Author(s): Santosa, Endi K*, Sun, Joseph C.* * MSK affiliated

Description
Summary from GEO:

"Natural Killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features, including antigen-specificity, clonal expansion, and memory. As such, NK cells share many transcriptional and epigenetic programs with their adaptive CD8+ T cell siblings. Various signals ranging from antigen, co-stimulation, and proinflammatory cytokines are required for optimal NK cell responses in mice and humans during virus infection; however, the integration of these signals remains unclear. In this study, we identified the transcription factor IRF4 as a signal integrator to coordinate the NK cell response during viral infection. Loss of IRF4 was detrimental to the expansion and differentiation of virus-specific NK cells. This defect was partially attributed to the inability of IRF4-deficient NK cells to uptake nutrients required for survival and memory generation. Altogether, these data suggest IRF4 is a signal integrator that acts as a secondary metabolic checkpoint to orchestrate the adaptive response of NK cells during viral infection."

See GEO record for overall design.
Subject of Study
Subject(s)
Access via GEO


Accession #: GSE236555

Access via BioProject


Accession #: PRJNA991566

Access Restrictions
Free to All
Access Instructions
The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications
Equipment Used
Illumina NovaSeq 6000
Dataset Format(s)
CSV, TAR, H5AD
Dataset Size
24.2 MB
Data Catalog Record Updated
2023-11-06