Stag2 regulates hematopoietic differentiation and self-renewal through alterations in gene expression and topological control

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UID: 11017

Author(s): Liu, Yu, Dekker, Job

Description: Summary from GEO:

"We performed HiC analyzed on wildtype and Stag2 knock-out hematopoietic progeitor cells and integrated with Stag2 ChIP-seq and RNAseq data to identy genes whose expression and tological structures are regulated by Stag2 during hematopoietic differentiation and self-renewal."

Overall design from GEO:

"Comparing HiC profiles of two wildtype hematopoietic progenitor cells with two Stag2 KO cells."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE119366

Access via BioProject

Accession #: PRJNA488956

Access via SRA

Accession #: SRP159429
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus. BioProject, and SRA databases provide open access to these files.
Associated Publications: Viny A, Bowman R, Liu Y, Lavallée V, Eisman S, Xiao W, Durham B, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete I, Witkin M, Azizi E, Baslan T, Ott C, Pe'er D, Dekker J, Koche R, Levine R. Cohesin members STAG1 and STAG2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation. Cell Stem Cell. 2019; 25(5):682-696.e8.
Equipment Used: Illumina HiSeq 4000
High throughput gene sequencing system
Dataset Format(s): Microsoft Excel, TAR, PNG, BEDGRAPH
Dataset Size: 30.62 MB (3 XLSX files), 6.57 MB (4 BEDGRAPH files), 3.907 GB (3 TAR files)

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