Chromatin interaction of ERG and AR in established prostate cancer

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UID: 11051

Author(s): Carver, Brett S.

Description: Summary from GEO:

"The current study defines the how ERG, PTEN, and AR inteact to regulate the transciptome in established prostate cancers. Prostate cancer organoids were derived from established prostate cancer in GEM models harboring ERG over-expression and/or loss of PTEN and cultured in vitro using prostate epithelial organoid culture conditions. The established organoids were then isolated as individual clones in triplicate and CRISPR strategies were employeed to knock out ERG and AR. ChIP seq was performed under standard growth and media conditions."

Overall design from GEO:

"12 samples with 3 genotype in 4 conditions."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE112414

Access via BioProject

Accession #: PRJNA445955

Access via SRA

Accession #: SRP136603
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus. BioProject, and SRA databases provide open access to these files.
Associated Publications: Mao N, Gao D, Hu W, Hieronymus H, Wang S, Lee Y, Lee C, Choi D, Gopalan A, Chen Y, Carver B. Aberrant expression of ERG promotes resistance to combined PI3K and AR pathway inhibition through maintenance of AR target genes. Molecular Cancer Therapeutics. 2019; 18(9):1577-1586.
Equipment Used: Illumina HiSeq 2000
High throughput gene sequencing system
Dataset Format(s): TAR, BW
Dataset Size: 2.3 GB

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