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Prostate Adenocarcinoma (MSK, Cancer Cell 2010): Comprehensive profiling of 218 prostate tumors (181 primaries, 37 metastases) and 14 prostate cancer cell lines and xenografts

UID: 11066

Author(s): Taylor, Barry Stephen*, Schultz, Nikolaus D.*, Hieronymus, Haley, Gopalan, Anuradha*, Xiao, Yonghong, Carver, Brett S., Arora, Vivek K., Kaushik, Poorvi, Cerami, Ethan, Reva, Boris, Antipin, Yevgeniy, Mitsiades, Nicholas*, Landers, Thomas, Dolgalev, Igor, Major, John E., Wilson, Manda*, Socci, Nicholas D.*, Lash, Alex E.*, Heguy, Adriana*, Eastham, James A.*, Scher, Howard I., Reuter, Victor*, Scardino, Peter T., Sander, Chris, Sawyers, Charles L.*, Gerald, William L. * MSK affiliated

Description
This dataset contains genomic profile samples, mutation information, and sequencing data from 218 prostate tumors, including 181 primaries and 37 metastases, and 14 prostate cancer cell lines and xenografts. After generating a map of CNAs across the dataset, the authors of this study used matching mRNA and microRNA transcriptome and exon resequencing data to define the frequency of alterations in several common signal transduction pathways, explore various candidate genes within a few selected regions of copy-number gain and loss and correlate genomic alterations to clinical outcome. The integrative genomic profiling of these tumors provides a foundation for discoveries that can impact disease understanding and treatment
Subject of Study
Subject(s)
Access Restrictions
Free to All
Access Instructions
This cBioPortal for Cancer Genomics dataset is publicly available for viewing online as tables, graphs, and/or charts. The data is also available for download in its entirety as a tarball or as individual TSV (tab separated value) files. Some features are only available by logging in with a Google or Microsoft account. These features include storing your virtual studies and groups which allows you to access your studies and groups from any computer, and to allow cBioPortal to remember your study view charts preferences for each study (i.e. order of the charts, type of charts and visibility). Login is optional and not required to access any of the other features of cBioPortal.
Associated Publications
Data Type
Software Used
Integrative Genomics Viewer (IGV)
Dataset Format(s)
TSV
Dataset Size
45 KB
Data Catalog Record Updated
2023-11-28