Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

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UID: 11094

Author(s): Kentsis, Alex* * MSK affiliated

Description: High-resolution CRISPR functional genomics reveals critical vulnerabilities of the NuRD complex for fetal hemoglobin control

Subject of Study

Subject(s)

Access via PRIDE

Accession #: PXD009793
Access Restrictions: Free to All
Access Instructions: All public datasets available in PRIDE Archive in the repository can be accessed via the website by FTP link, Web Service (for programmatic access), and the PRIDE Inspector stand-alone tool.
Associated Publications: Sher F, Hossain M, Seruggia D, Schoonenberg V, Yao Q, Cifani P, Dassama L, Cole M, Ren C, Vinjamur D, Macias-Trevino C, Luk K, McGuckin C, Schupp P, Canver M, Kurita R, Nakamura Y, Fujiwara Y, Wolfe S, Pinello L, Maeda T, Kentsis A, Orkin S, Bauer D. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nature Genetics. 2019; 51(7):1149-1159.
Equipment Used: Orbitrap Fusion Lumos
Software Used: MaxQuant
A quantitative proteomics software package designed for analyzing large mass-spectrometric data sets. It is specifically aimed at high-resolution MS data.
Dataset Format(s): CSV, RAW, zip
Dataset Size: 27 GB

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