Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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UID: 11098

Description: To date few DDK substrates other than the MCM helicase have been identified, and none are implicated in fork protection or restart. Here we searched for such factors, using SILAC and quantitative mass spectrometry to identify the DDK phosphoproteome during fork stalling.

Subject of Study

Subject(s)

Access via PRIDE

Accession #: PXD014399
Access Restrictions: Free to All
Access Instructions: All public datasets available in PRIDE Archive in the repository can be accessed via the website by FTP link, Web Service (for programmatic access), and the PRIDE Inspector stand-alone tool.
Associated Publications: Jones M, Gelot C, Munk S, Koren A, Kawasoe Y, George K, Santos R, Olsen J, McCarroll S, Frattini M, Takahashi T, Jallepalli P. Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell. 2021; 81(3):426-441.e8.
Equipment Used: Q Exactive
Mass Spectrometer
Software Used: Mascot
For identification, characterisation and quantitation of proteins using mass spectrometry data.

MaxQuant
A quantitative proteomics software package designed for analyzing large mass-spectrometric data sets. It is specifically aimed at high-resolution MS data.
Dataset Format(s): RAW, zip
Dataset Size: 33.3 GB

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