Proteomic analysis of SYNCRIP deficient HSPCs

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UID: 11103

Author(s): Kentsis, Alex* * MSK affiliated

Description: Alterations in SYNCRIP activity were found to alter gene transcription in leukemia cells. The effects of transcription alterations on expression of the corresponding proteins were investigated by LC/MSMS

Subject of Study

Subject(s)

Access via PRIDE

Accession #: PXD019779
Access Restrictions: Free to All
Access Instructions: All public datasets available in PRIDE Archive in the repository can be accessed via the website by FTP link, Web Service (for programmatic access), and the PRIDE Inspector stand-alone tool.
Associated Publications: Herrejon Chavez F, Luo H, Cifani P, Pine A, Chu K, Joshi S, Barin E, Schurer A, Chan M, Chang K, Han G, Pierson A, Xiao M, Yang X, Kuehm L, Hong Y, Nguyen D, Chiosis G, Kentsis A, Leslie C, Vu L, Kharas M. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature Communications. 2023; 14:2290.
Equipment Used: Orbitrap Fusion Lumos
Software Used: Peaks
a software platform with complete solutions for discovery proteomics, including protein identification and quantification, analysis of post-translational modifications (PTMs) and sequence variants (mutations), and peptide/protein de novo sequencing
Dataset Format(s): CSV, RAW
Dataset Size: 6.5 GB

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