Integrative analysis reveals unique structural and functional features of the Smc5/6 complex

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UID: 11114

Author(s): Kentsis, Alex* * MSK affiliated

Description: Cross-linking mass spectrometry data for integrative structural analyses of the Smc5/6 holo-complex from budding yeast. Electron microscopy, crosslinking mass spectrometry, and computational modeling reveal that while the complex shares an overall organization with other SMC complexes, it possesses several strikingly different features.

Subject of Study

Subject(s)

Access via PRIDE

Accession #: PXD023164
Access Restrictions: Free to All
Access Instructions: All public datasets available in PRIDE Archive in the repository can be accessed via the website by FTP link, Web Service (for programmatic access), and the PRIDE Inspector stand-alone tool.
Associated Publications: Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel D, Zhao X. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118(19):e2026844118.
Equipment Used: Orbitrap Fusion Lumos
Software Used: Percolator
a software for postprocessing of shotgun proteomics data
Dataset Format(s): RAW, MSF

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