Target identification of CQ31, a selective activator of the CARD8 inflammasome

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UID: 11118

Author(s): Griswold, Andrew*, Bachovchin, Daniel* * MSK affiliated

Description: Target identification of CQ31 using the photoreactive diazirine-alkyne probe, CQ73.

Subject of Study

Subject(s)

Access via PRIDE

Accession #: PXD027707
Access Restrictions: Free to All
Access Instructions: All public datasets available in PRIDE Archive in the repository can be accessed via the website by FTP link, Web Service (for programmatic access), and the PRIDE Inspector stand-alone tool.
Associated Publications: Rao S, Chen Q, Wang Q, Orth-He E, Saoi M, Griswold A, Bhattacharjee A, Ball D, Huang H, Chui A, Covelli D, You S, Cross J, Bachovchin D. M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nature Chemical Biology. 2022; 18(5):565-574.
Equipment Used: Orbitrap Fusion Lumos
Software Used: MaxQuant
A quantitative proteomics software package designed for analyzing large mass-spectrometric data sets. It is specifically aimed at high-resolution MS data.
Dataset Format(s): RAW, TXT
Dataset Size: 1.2 GB

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