RNA-seq of human thyroid cancer cell lines expressing sh-mirE-YAP or YAPS127A

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UID: 11148

Author(s): Garcia-Rendueles, Maria E. R.*, Fagin, James A.*, Knauf, Jeffrey A*, Saqcena, Mahesh* * MSK affiliated

Description: Summary from GEO:

"We performed high-throughput RNA sequencing of stable lines with dox-inducible expression of sh-mirE-YAP or of the constitutively nuclear YAPS127A mutant to investigate YAP dependency and its role in tumorogenesis."

Overall design from GEO:

"mRNA profiles of human thyroid cancer cell lines treated with/without doxycyclin to express sh-mirE-YAP or of the constitutively nuclear YAPS127A mutant."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE198379

Access via BioProject

Accession #: PRJNA814733
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Garcia-Rendueles M, Krishnamoorthy G, Saqcena M, Acuña-Ruiz A, Revilla G, de Stanchina E, Knauf J, Lester R, Xu B, Ghossein R, Fagin J. Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors. Molecular Cancer. 2022; 21:213.
Equipment Used: Illumina NovaSeq 6000
Dataset Format(s): TXT
Dataset Size: 1.4 MB

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