Oxoeicosanoid signaling promotes early antimicrobial defense in zebrafish (Danio rerio)

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UID: 11168

Author(s): Ma, Yanan*, Hui, King Lam*, Gelashvili, Zaza*, Niethammer, Philipp* * MSK affiliated

Description: Summary from GEO:

"RNAseq was performed on hcar1-4+/+ and hcar1-4-/- zebrafish larvae with (2 h and 4 h) or without (0 h) Pseudomonas aeruginosa (PA) ear infection. The transcriptome profile generated here reveals PA14 infection-induced differential gene expression patterns between hcar1-4-/- and hcar1-4+/+ siblings."

Overall design from GEO:

"Pseudomonas aeruginosa resuspended in standard E3 was injected into the otic vesicle of hcar1-4+/+ and hcar1-4-/- zebrafish larvae. Uninjected zebrafish larvae served as control. Total RNA was extracted before or after 2 hours and 4 hours of infection, and processed to following sequencing."

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE201604

Access via BioProject

Accession #: PRJNA832297
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Ma Y, Hui K, Gelashvili Z, Niethammer P. Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 2023; 42(1):111974.
Equipment Used: Illumina HiSeq 2500
High throughput sequencing system
Dataset Format(s): TXT
Dataset Size: 3.4 MB

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