Single cell RNA sequencing analysis of purified MAIT and Vdelta2 (Vd2) subset of gamma delta T cells in allo-HCT patients and healthy controls

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UID: 11169

Author(s): Kousa, Anastasia*, Andrlova, Hana*, Chaligne, Ronan, Masilionis, Ignas*, Van Den Brink, Marcel R. M.*, Markey, Kate* * MSK affiliated

Description: Summary from GEO:

"We report the transcriptional changes of MAIT and Vd2 cells in the patients receiving allogeneic stem cell transplantation with good outcome compared to MAIT and Vdelta2 cells of healthy volunteers"

Overall design from GEO:

"Comparison of MAIT and Vd2 cells collected from 5 patients and 5 healthy control subjects"

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE194328

Access via BioProject

Accession #: PRJNA800335
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Andrlová H, Miltiadous O, Kousa A, . . . , Markey K. MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT. Science Translational Medicine. 2022; 14(646):eabj2829.
Equipment Used: Illumina NovaSeq 6000
Dataset Format(s): PDF, CSV, HTML, TSV, TAR, PNG, MTX, TXT, H5, H5AD, JSON
Dataset Size: 27.5 GB

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