Next Generation Sequencing Analysis of OX40hi Treg and OX40lo Treg cells from mouse tumors and spleens

Default Boolean Operator: Terms in a search string will be connected by the AND operator, EXAMPLE: searching genomic melanoma will produce the same results as genomic AND melanoma .
AND, OR, NOT: Combine terms in a search with the boolean operators AND (to add specificity), OR (to broaden), or NOT (to eliminate a term). Operators must be capitalized (all other search terms are not case-sensitive).
Wild Card: Add wild card symbols * (open-ended) and ? (single character) to truncate terms. EXAMPLE: searching gen* shows results for 'gene', 'genetic', 'genomic, etc. Searching gene? returns results for 'gene' or 'genes' but not for 'genome'.
Phrase Searching: Enclose search in quotation marks "keyword or search term" to search for an exact phrase. EXAMPLE: "transcription factors" returns results for records where transcription is immediately followed by the word factors .
Diacritics: Words containing diacritics translate those characters to non-diacritic form. EXAMPLE: massague returns results for Massague&#769 .
Filter by: Located on the homepage (left panel), use filters to search for records or narrow the search. From search results page, filters can be removed by clicking on the term at the top of the page.

UID: 11211

Author(s): Tan, Adrian, Yang, Ning*, Deng, Liang* * MSK affiliated

Description: Summary from GEO:

"Based on RNA-seq technology, we studies gene expression profiles in Treg cells isolated from mouse tumors and spleens. We identified differential gene expressions comparing OX40hi Treg with OX40lo Treg cells from tumors and spleens. The difference of Trges in tumors and spleens were also identified."

Overall design from GEO:

"Foxp3-GFP mice were intradermally implanted with B16 cells at 5x10^5 cells at the right side. After 7-10 days, tumors and spleens were dissected and digested into single cells. After staining with antibodies against CD45, CD3, CD4 and OX40, OX40hiGFP+ and OX40loGFP+ cells were sorted in BD FACSAria cell sorter."

Subject of Study

Subject(s)

OncoTree Cancer Type(s)

Melanoma

Do you have or know of a dataset that should be added to the catalog? Let us know!