Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [ATAC-Seq]

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UID: 11216

Author(s): Jain, Nayan*, Zhao, Zeguo*, Koche, Richard Patrick*, Dobrin, Anton*, Sadelain, Michel W. J.* * MSK affiliated

Description: Summary from GEO:

"Comparing genome accessibility profiles (ATACseq) of WT and SUV39H1-edited CAR T cells"

Overall design from GEO:

"Unedited and SUV39H1-edited human CAR T cells were sorted from bone marrow (at day 50) of NSG mice that had undergone multiple rounds of NALM6 rechallenge"

Subject of Study

Subject(s)

Access via GEO

Accession #: GSE245186

Access via BioProject

Accession #: PRJNA1027332
Access Restrictions: Free to All
Access Instructions: The NCBI Gene Expression Omnibus and BioProject databases provide open access to these files.
Associated Publications: Jain N, Zhao Z, Koche R, Antelope C, Gozlan Y, Montalbano A, Brocks D, Lopez M, Dobrin A, Shi Y, Gunset G, Giavridis T, Sadelain M. Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T-cell function. Cancer Discovery. 2024; 14(1):142-157.
Equipment Used: Illumina HiSeq 4000
High throughput gene sequencing system
Dataset Format(s): TXT
Dataset Size: 3.3 MB

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